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Clinical Trials

Surgical Treatment for Ischemic Heart Failure (STICH) Trial

STICH is a clinical trial which will help doctors determine which treatments will help patients with 1) heart failure and 2) coronary artery disease live longer. Heart failure affects approximately 5 million Americans and is manifested by symptoms which can include shortness of breath, fatigue, swelling in feet, ankles, and legs, and weight changes. This study is worldwide in 90 medical centers and 15 countries.

Common causes of heart failure may include damage to the heart by a myocardial infarction, commonly known as a heart attack, disease or injury to a heart valve, high blood pressure, and diabetes.

There are three possible treatments being compared in the trial. Depending upon the results of tests that qualify the patient for the trial, the patient will be randomly assigned to either 1) medical therapy alone, 2) medical therapy with coronary artery bypass surgery, or 3) medical therapy with coronary artery bypass surgery and surgical ventricular restoration.

Surgical ventricular restoration, or the DOR procedure, is a surgical procedure that decreases the size of the left ventricle, which improves the heart’s ability to pump blood to the body. The web site CTSnet.org/doc/2630 has an explanation with a cartoon to assist in explaining the procedure.

To learn more information regarding heart failure visit CHFpatients.com. The STICH trial has two web sites:

  • Stichtrial.org explains the trial and has a patient synopsis of the trial
  • Nih.gov also has information to assist with learning about the mission of NIH research and the STICH trial in particular.

There are two more sites to learn more about heart disease:

Eligibility for Enrollment

  • Ischemic (blockage in a heart artery) heart failure
  • Symptoms of heart failure

Primary Investigators: Vaughn Starnes, MD, Mark Cunningham, MD, Mark Barr, MD

Sponsor: National Institutes of Health

If you are interested in participating, please contact us at (323) 442-5849 to see if you qualify.


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